People who take Viagra have lower risk of Alzheimer’s: study

People who take Viagra have lower risk of Alzheimer’s: study

Viagra might help to treat Alzheimer’s disease, according to researchers who have been using the impotence drug to study the effects it has on the brain.

Though more studies are needed, researchers in Cleveland found that men who were taking the blue pill, also known as sildenafil, had a lower risk of Alzheimer’s, following analysis of a database of over 7.2 million patients spanning six years, BBC News reported Monday.

The team also found in lab studies that those who took higher than usual doses of the pill — best known for erectile dysfunction — displayed an increase in brain cell growth and reduced protein accumulation, according to the outlet.

People-who-take-Viagra-have-lower-risk-of-Alzheimers-study
People who take Viagra have lower risk of Alzheimer’s: study
Viagra might help to treat Alzheimer’s disease, according to researchers who have been using the impotence drug to study the effects it has on the brain.
Though more studies are needed, researchers in Cleveland found that men who were taking the blue pill, also known as sildenafil, had a lower risk of Alzheimer’s, following analysis of a database of over 7.2 million patients spanning six years, BBC News reported Monday.
The team also found in lab studies that those who took higher than usual doses of the pill — best known for erectile dysfunction — displayed an increase in brain cell growth and reduced protein accumulation, according to the outlet.

“Because our findings only establish an association between sildenafil use and reduced incidence of Alzheimer’s disease, we are now planning a mechanistic trial and a phase II randomized clinical trial to test causality and confirm sildenafil’s clinical benefits for Alzheimer’s patients,” research leader Dr. Feixiong Cheng reportedly told the Nature Aging journal.

Until that research is completed, University of Edinburgh Professor Tara Spires-Jones, an expert on brain research, advises people “not rush out to start taking sildenafil as a prevention for Alzheimer’s disease.”

Dr. Jack Auty, a Medical Sciences lecturer at the University of Tasmania, similarly said this is hardly the first indication of a drug that could help with Alzheimer’s, though that has yet to pan out, according to the BBC.

To repurpose an already existing drug would be both a cheaper and overall more efficient path than developing an entirely new treatment for the disease.

Originally meant to treat the heart, Viagra’s ability to relax blood vessels and subsequently improve blood flow in other parts of the body led to its use for ED as well as pulmonary hypertension — for men and women alike — which affects the lungs, according to the outlet.

Though the exact causes of Alzheimer’s, a type of dementia, are still being probed, it’s known that those who have it have abnormal protein deposits in their brains, BBC reports.

Viagra to treat Alzheimer’s disease? Cleveland Clinic researchers optimistic

(WJW) — A new study by the Cleveland Clinic indicates sildenafil, a therapy for erectile dysfunction (Viagra) and pulmonary hypertension (Revatio), may also be promising in the treatment and prevention of Alzheimer’s disease.

The findings by a research team led by Cleveland Clinic Dr. Feixiong Cheng were published in “Nature Aging.”

Through a large-scale analysis of a database of more than seven million patients, the team determined sildenafil is associated with 69 percent reduced incidence of Alzheimer’s disease.

That indicates the need for a follow-up clinical trial testing of the drug’s efficacy in patients with that disease, the press release states.

The team used computational methodology to screen and validate FDA-approved drugs as potential therapies for the disease, the release states.

“This paper is an example of a growing area of research in precision medicine where big data is key to connecting the dots between existing drugs and a complex disease like Alzheimer’s,” said Dr. Jean Yuan, program director of Translational Bioinformatics and Drug Development at the National Institute on Aging. “This is one of many efforts we are supporting to find existing drugs or available safe compounds for other conditions that would be good candidates for Alzheimer’s disease clinical trials.”

According to the Cleveland Clinic, without the development of new treatments, Alzheimer’s disease could impact 13.8 million Americans by 2050.

 

Cheng said the team is now planning a trial and phase II randomized clinical trial to confirm benefits for Alzheimer’s patients. They hope the approach is applied to other neurodegenerative diseases in the future.

 

RE-Studio Stream music: dj tiktok terbaru 2021, dj terbaru 2021, dj tiktok terbaru 2021 full bass, dj terbaru

Leave a Reply